Dr. Mario has been making house calls to sick toads being affected by a mystery virus. But treating the sickly toads will only postpone the inevitable. Help Dr. Mario solve the mysterious epidemic going on in the Mushroom Kingdom in this fun new SMW adventure!

Taking place after the destruction of the "God of Ruin" (also known as Golden Silver, the final boss) at the end of Gunstar Heroes, the explosion created four moons orbiting the Earth. However, many years later, the creation of a fifth moon reveals a plan to resurrect the malevolent Empire and Golden Silver once again.

Protagonists Red and Blue, named as such in tribute to the legendary warriors from the original Gunstar Heroes, combat the Empire as part of an organization called "The Third Eye". Together with Yellow, the Gunstars must travel to the moons, stop the resurrected Empire, and recapture the Treasure Gems, four mystical stones with an unknown power that drove the story of the previous game. Super Heroes has different storylines based on what difficulty is chosen and which character the player is playing as.

Most of Gunstar Super Heroes's characters are named after characters from the original Gunstar Heroes, and while many of these new characters bear distinct resemblances to the equivalent characters from the first game, one notable exception is Red, who is female, unlike the original Gunstar Red, who was male.

By plugging Sonic 2 into the top of Sonic & Knuckles using the "Lock-On" technology you can replay the game as Knuckles. However no such feature was included in the original game (instead, attaching Sonic 1 to the Sonic & Knuckles cartridge unlocked the full version of Blue Sphere).

This hack allows you to over come this limitation and play Sonic the Hedgehog 1 as Knuckles.

As a prequel to Four Swords, the plot of The Minish Cap revolves around the backstory of Vaati and the birth of the Four Sword, which were important elements of Four Swords and Four Swords Adventures. The Minish, also referred to as the Picori by the Hyruleans, are a race of tiny creatures that bestowed a young boy with a green garment, a sword, and a shining golden light to drive back the darkness many years before the game is set. There are three types of Minish: Town, Forest, and Mountain.