Monsters can jump and climb buildings, and punch enemies and buildings. Buildings also take damage when jumped on by a monster. The player's monster receives damage from enemy bullets, grenades, shells and so forth, and from falls. Damage is recovered by eating appropriate food such as fruit, roast chicken, or soldiers. If a monster takes too much damage, it reverts back into a naked human and starts walking off the screen sideways, covering its genitals with its hands. While in this state, the player can be eaten by another player. If the player continues, the human mutates back into the monster, or flies in on a blimp if off-screen, with a full life bar.

Crunch the Concrete! Snack on a Soldier! Trash a Trolley! Join arcade legends George the Ape, Ralph the Wolf and Lizzie the Lizard on a mission of mass destruction from coast to coast. Go on a RAMPAGE!

Crunch the Concrete! Snack on a Soldier! Trash a Trolley! Join arcade legends George the Ape, Ralph the Wolf and Lizzie the Lizard on a mission of mass destruction from coast to coast. Go on a RAMPAGE!

Mass destruction has never been so much fun! And arcade superstars Ralph the Wolf, George the Ape, and Lizzie the Lizard make a riotous wrecking crew. So go wild! Crunch the concrete. Trash a trolley. Snack on a soldier. Have an office building for lunch. Go on a RAMPAGE!

A unique game where you play the role of a monster going on a rampage and destroying entire cities, one building at a time.
A great stress reliever!

George, Lizzie, and Ralph have been captured for the world to see. Scumlabs, who has just rebuilt their facilities in Salt Lake City, causes another accident that results in three new monsters: Curtis, a mouse, Boris, a rhinoceros, and Ruby, a lobster. Players choose one of the three original monsters to rescue. The player then uses the characters in the part of the world where the rescue is held. They work as a collective to break buildings, eat people, and destroy cars and this creates competition among players. When a player (literally) unlocks Ralph, Lizzie, or George, then they become playable characters. Once all the monsters are rescued, aliens begin to invade the earth, leaving the monsters the only ones who can save the planet they just helped partially destroy. After fending off the invasion on Earth, the monsters rescue Myukus (a cyclops-like alien) from Area 51 before chasing the aliens through space, destroying the aliens' bases throughout the Solar System and eventually rampaging through their home world.

Story:
George, Lizzie, and Ralph have been released due to an explosion at a Scumlabs facility. The trio begin to destroy all of Scumlabs' bases scattered throughout the world and kill its employees. In the last levels, Scumlabs CEO Eustace DeMonic turns himself into a monster in an attempt to combat George, Lizzie, and Ralph, but is defeated during a battle on a lunar base. After this, the only surviving Scumlabs employee, Dr. Betty Veronica, tries to kill the monsters with a ray gun on her spaceship, but this only shrinks them and they wind up inside her ship.

Gameplay:
Like in the first Rampage game, the goal of every stage is to destroy all the buildings in each city while avoiding or destroying the military forces. If the player takes too long in destroying the city, jets will fly in and bomb the remaining buildings, ending the stage with a lower score.